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IDH2(R172K)
| 货号: 26163 |
| 基因符号: IDH2; D2HGA2; ICD-M; IDH; IDHM; IDP; IDPM; mNADP-IDH |
| 描述: IDH2(R172K) 小鼠单克隆抗体 |
| 背景: Isocitrate dehydrogenase (IDH) catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. The isocitrate and isopropylmalate dehydrogenases family has three members, IDH1, IDH2 and IDH3. IDH2 plays a role in intermediary metabolism and energy production. Defects in IDH2 are the cause of D-2-hydroxyglutaric aciduria type 2 (D2HGA2). Somatic mosaic mutations of this protein have also been found associated to Ollier disease and Maffucci syndrome, and R172K IDH2 mutations do exist in diffusely infiltrative gliomas. |
| 免疫原: A synthetic peptide from the internal region of IDH2 which includes the mutation of R172K, human origin. |
| 经过测试的应用: ELISA, WB, IHC |
| 推荐稀释度： ELISA: 1:1000-1:5000 WB: 1:100-1:1000 IHC: 1:50-1:100 IHC: 1:10-1:100 |
| 浓度: 1 mg/ml |
| 种属反应性: Mouse |
| 形式: Liquid |
| 克隆性： Monoclonal |
| 亚型: |
| 纯化:: Purified from ascites |
| Preservative: No |
| 成分: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| 种属反应性: recognizes R172K mutant, but not wild type IDH2 of vertebrates. |
| 储存条件:: Store at -20°C. Avoid repeated freezing and thawing |
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