5α-Dihydrotestosterone

5α-Dihydrotestosterone 是一种活性组织雄激素，可用于研究去势抵抗性前列腺癌。

别名 雄诺龙, Dihydrotestosterone, Androstanolone, 5α-DHT

Dihydrotestosterone(DHT) is an endogenous androgenic steroid and hormone that acts as an agonist for androgen receptors.Dihydrotestosterone regulation of miRNA expression. CD44 expression and cell adhesion to hyaluronic acid (HA) were down-regulated when cells were treated with Dihydrotestosterone or transfection with a miR-328-3p mimic. Altered miRNA levels when luminal breast cancer MCF-7 cancer cancer cells were treated with Dihydrotestosterone . The expression of one critical miRNA, namely let-7a-d, was also found to be up-regulated in Dihydrotestosterone-treated MDA-MB-453 cells . Treatment of MDA-MB-453 cells with Dihydrotestosterone causes down-regulation of miR-125b and miR-100 in association of increased expression of matrix metalloprotease 13, a target of both miRNAs . Dihydrotestosterone treatment enhanced STAT5 phosphorylation and promoted proliferation of all CRPC cells. On immunofluorescence, activation of STAT5 and GR translocating into the nucleus after Dihydrotestosterone treatment .Dihydrotestosterone induced early hair regression, hair miniaturization, hair density loss, and changes in hair morphology in male C57BL/6 mice . The presence of the possible negative regulation of cell proliferation by Dihydrotestosterone. Moreover, cell proliferation related to urethral tube formation was revealed to be Dihydrotestosterone dose dependent . Dihydrotestosterone-treated ovariectomized mice had free access to food (free-feeding), they had increased food intake and higher body weight compared with control animals. These mice also had a significantly greater accumulation of fat in the liver and exhibited increased fasting glucose, impaired glucose tolerance, and resistance to leptin . Promastigotes in the presence of Dihydrotestosterone produced significantly larger lesions in BALB/c earlobes .